INVESTIGATE
disease mechanisms and novel therapeutic approaches associated with MAPK8IP3 genetic variants
About
Spearhead Research Initiatives
The Wolverine Foundation spearheads groundbreaking research to develop effective treatments for MAPK8IP3-related genetic disorders and potentially other ultra-rare central nervous system diseases. By leveraging state-of-the-art scientific models, medical innovations, and collaborative knowledge sharing, the foundation accelerates discoveries that promise to transform the landscape of rare disease therapeutics.
Advancing Research and Therapeutic Strategies for MAPK8IP3-Related Neurodevelopmental Disorder
By addressing the significant challenges and leveraging the opportunities presented by the MAPK8IP3-related neurodevelopmental disorder, the Wolverine Foundation is poised to make a transformative impact on the lives of affected individuals and their families.This genetic disease has only recently been discovered with scant research. The Wolverine Foundation serves to advance research and discover novel therapeutic approaches to treat the neuro-developmental disease caused by genetic variations in the gene MAPK8IP3. The Foundation aims to accomplish these goals by supporting a team of researchers to:
MANAGE
a diverse portfolio of research projects that encourages scientific collaboration to more directly connect academic research, drug discovery and clinical development.
WE WORK IN A NUMBER OF DIFFERENT WAYS
ACADEMICS
We fund and work with academic MAPK8IP3 researchers at universities around the world
COLLABORATIVE ENABLER
We act as a ‘collaborative enabler’ for any research group that wants to work on MAPK8IP3 by making resources (mouse models, clinical samples, etc.) freely available to the MAPK8IP3 research community.
PARTNERSHIP
We invite the possible partnership with biotech and pharmaceutical companies to develop potential drugs
In Partnership With Research Teams Around The World
A big part of The Wolverine Foundation’s remit is to collaboratively enable any researcher that is interested in working on The MAPK8IP3 Genetic Mutation by lowering the barrier to entry through the provision of MAPK8IP3 domain knowledge, animal models or funding. In our role as a collaborative enabler, The Wolverine Foundation seeks to bring the right partners together to identify and address critical scientific issues to increase the understanding of MAPK8IP3 and hasten the development of therapeutic approaches to clinical evaluation as rapidly as possible. We also work closely with colleagues at the patient advocacy organizations (like the CureMAPK8IP3.com patient family group) around the world to forge links between patients/families and researchers/clinicians to speed the drug development process.
Research
THE WOLVERINE FOUNDATION RESEARCH TEAMS
The Wolverine Foundation has assembled a community of researchers who are working together to fulfill the foundation’s goals of defining disease mechanisms, determining impacts of MAPK8IP3 genetic variants, and discovering drug therapies. In order to accomplish these goals, researchers are using a variety of cell and animal models to assist in experimental hypothesis testing and drug discovery. Human embryonic kidney (HEK), patient-derived induced pluripotent stem cells (iPSCs), CRISPR/Cas9 modified worms, zebrafish, and mice models of patient variants are all being developed in order to assure that all avenues of research are explored. Models being created will be made available to the research community for future collaborations and experiments to continually expand research into MAPK8IP3 genetic disease