The Lambert Lab at The Mayo Clinic
Laura J. Lambert, Ph.D., is a biomedical scientist who specializes in creating and studying genetically engineered preclinical models of patient alleles and understanding the role of genetic variants in disease. Her broad research interests include repurposing drugs, discovering novel therapeutics and advancing genetic therapies. The Lambert Lab is studying the influence of specific genetic variants of the MAPK8IP3 gene on cognitive and behavioral traits in mice.
The research aims to understand how these MAPK8IP3 variants may lead to deficits in cognitive functions, such as memory, attention, and problem-solving, as well as behavioral issues.
About Dr Lambert
Dr. Lambert has extensive experience creating, characterizing and treating patient-specific models of human disease. She also uses gene therapy and other therapeutic approaches for rare genetic conditions. These include exon skipping, ribozymes, CRISPRa and CRISPRi, prime editing, and base editing.
Focus areas
- Genome editing.
- CRISPR and gene replacement therapy.
- Nonviral delivery vectors.
- Patient-specific and patient-derived precision modeling.
- N=1 drug repurposing.
Significance to patient care
Dr. Lambert’s research program works to improve care for people with rare diseases by making it easier to diagnose them, using laboratory research to understand these diseases better and turning personalized treatments into practical medical solutions.
Professional highlights
- Researcher, Minnesota Rare Disease Advisory Council, 2024-present.
- Co-investigator, Minnesota Partnership for Biotechnology and Medical Genomics, 2023-present.
- Director, Functional Omics Resource, Mayo Clinic, 2022-present.
Presented and produced as part of the 2024 Individualizing Medicine Conference in Rochester, MN September 11 and 12, from the Center for Individualized Medicine at Mayo Clinic. Shared with permission by Mayo Clinic.